The pyrazolone ring is an important structural moiety found in numerous pharmaceutically active compounds. This is mainly due to the ease preparation and the important versatile biological activity. When pyrazolones were discovered, they were mostly useful as a anti-inflammatory and analgesic but in recent times, they are known to exhibit antioxidant, anticancer, antibacterial and several other pharmacological actions like antifungal, protein-kinase inhibitor, anti inflammatory, analgesic, antipyretic, anticancer, anticonvulsant, ant diabetic, plant growth regulator ,and herbicidal. These derivatives were withdrawn from the market because of their adverse effects such as agranulocytosis, skin rashes and blood dyscrasis. So, structural modification of pyrazolones is necessary to minimize the side effect and to improve its therapeutic application. But, recently it again gain place in market due to their versatile actions especially in cardiovascular diseases. This review emphasized the recent researches in pyrazolones in various diseases and disorders.
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